Testicular mesothelioma

What Is Testicular Mesothelioma?

Testicular mesothelioma is a cancer that develops on the testicular membrane. This rare
condition, also known as tunica vaginalis testis mesothelioma, accounts for less than 5% of all
mesothelioma cases.
The tunica vaginalis is the mesothelial lining of the testicles. It's a vital tissue that permits the
testicles to move around freely.
It is thought to be caused by asbestos fibers being trapped deep within the
protective testicle linings after the infected person inhales or ingests them. The patient will begin
to experience symptoms after a period of 10-50 years.
What Causes Testicular Mesothelioma?
Doctors do not yet understand how asbestos exposure might cause a primary tumor to grow on
the tunica vaginalis, the bag of serous membrane that protects the testes, unlike pleural or
peritoneal mesothelioma, which can easily be connected to asbestos exposure.
On the surface of the tunica vaginalis, it appears as solid, white-yellow nodules. The nodules
may eventually enclose the contents of the scrotum, thickening the membrane.
Local damage and inflammation may also contribute to its progression. Some cases show up
with no discernible risk factors.
Most testicular mesothelioma patients, like those with pleural and peritoneal mesothelioma, have
vague symptoms that might be mistaken for other disorders and diseases, such as an inguinal
hernia or other testicular malignancies. Asymptomatic instances with a diagnosis based on a
standard physical examination have also been seen by doctors.
Testicular mesothelioma tumors can be secondary, and in a few cases, they've been related to

peritoneal mesothelioma metastasis. Patients may suffer additional symptoms affecting the belly,
such as abdominal pain or edema, in certain cases. Some of the frequent symptoms, such as
persistent hydrocele, have also been linked to a testicular mesothelioma diagnosis, according to

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Common Symptoms and Signs of Testicular Mesothelioma
 The testicle has a bulge or tumor on it.

 Hydrocele is a condition in which a person has (fluid buildup in the scrotum causing
 Testicular discomfort
 Epididymis inflammation is a condition in which the epididymis becomes inflamed
 Prognosis and Survival Rate
Men who develop this malignancy have a far better prognosis than those who develop other
kinds of mesothelioma.
According to a 2019 study published in the journal Urology, over 49% of patients survive five
years following diagnosis and 33% survive ten years.
When compared to other mesotheliomas and epithelioid subtypes, patients with the biphasic cell
type of malignancy had a lower overall survival rate.
The epithelioid cell type was found in 75% of the 113 testicular mesothelioma patients in the

research. Patients who were older and had tumors that were larger than or equivalent to 4 cm in
diameter had a poor prognosis.
How Is Testicular Mesothelioma Diagnosed?
A biopsy is the definitive way to definitively confirm a cancer diagnosis. This entails extracting a
sample of tumor tissue and sending it to a lab for testing.
Doctors use immunohistochemical staining to detect if the patient has testicular mesothelioma or
another disease by examining the sample.
In order to determine a patient's prognosis and design a suitable treatment strategy, it's crucial to
know what stage of cancer they have. Doctors don't have enough data to construct a proper
staging system because this type of mesothelioma is so rare. Instead, doctors will look at generic
mesothelioma features to see how far a patient's disease has progressed and how it might
progress in the future.
A localized tumor is indicated by stage 1 or stage 2 testicular mesothelioma. Patients will have
additional treatment options, such as surgical resection, if cancer growth is limited or non-
existent. Treatment choices grow increasingly limited when the cancer progresses and spreads to
lymph nodes and other organs, and the prognosis worsens.

What Causes Testicular Mesothelioma?

Asbestos exposure is the same thing that causes all other types of mesothelioma. Asbestos was a hazardous and toxic chemical that was widely employed in building and industry throughout the twentieth century.

Many people were exposed to asbestos on a regular basis, and their exposure was sometimes at dangerously high levels. Asbestos exposure causes not only mesothelioma, but also other lethal respiratory diseases and malignancies.

While other types of mesothelioma, such as pleural, peritoneal, and pericardial mesothelioma, have been linked to asbestos exposure, it is unknown if testicular mesothelioma is caused only by asbestos exposure.

According to some statistics, only around half of all instances with testicular mesothelioma had a known history of asbestos exposure.

What else could trigger testicular mesothelioma, however, is still unknown. Asbestos causes testicular mesothelioma by causing a biological mutation of healthy cells into abnormal cells, which is driven by this known carcinogen.

How Is Testicular Mesothelioma Diagnosed?

A doctor will arrange imaging testing, most commonly an ultrasound, once a patient presents with symptoms or if a testicular irregularity is discovered during an examination. A testicular mesothelioma ultrasound is a low-risk, non-invasive treatment that creates an image of the scrotum using sound waves. Ultrasound may reveal any swelling, such as a hydrocele, or any lumps that have developed. According to studies, approximately 56 percent of testicular mesothelioma patients have a hydrocele, whereas approximately 33 percent have a solid mass in the testes.

Following an ultrasound, a doctor will most likely perform a blood test or assay to evaluate the cause of symptoms and, hopefully, provide early cancer detection. To rule out more common types of testicular cancer, blood tests will be quite useful. There are biomarkers in the blood that doctors can search for in mesothelioma, such as SMRP, to help discover the asbestos cancer early, but these have not been investigated in testicular mesothelioma.

A blood test can help to rule out mesothelioma, but a tissue biopsy is the only way to be sure. The biopsy, which determines cell type and stage, is usually the last step in the diagnostic process. This will then provide information about a patient’s prognosis. Additional tests may be needed to detect whether the cancer has spread to the lymph nodes or other regions of the body, as well as whether there are any secondary tumors.

Mesothelioma of the Tunica Vaginalis Testis

This kind of mesothelioma is extremely rare, with just about 100 instances ever diagnosed and documented. The majority of males diagnosed with testicular mesothelioma are over the age of 45, however it can strike men as early as their 20s. [1] About half of the cases have been linked to asbestos, but the link is weaker than in pleural or peritoneal mesothelioma, which are the more frequent varieties of this malignancy.

This malignancy, like other kinds of mesothelioma, begins with a primary tumor of the mesothelium. Many of the body’s organs are surrounded by this thin, double-layered tissue. The tunica vaginalis is the mesothelium that surrounds the testicles, and cancer of this tissue is known as mesothelioma of the tunica vaginalis or testicular mesothelioma.

What is Testicular Mesothelioma’s Prognosis?

Because it is more localized, testicular mesothelioma has a better prognosis than other types of the disease, and there have been several documented cases of benign tunica vaginalis mesothelioma. The median survival time has been reported to be around 20–23 months, while some individuals have lived for years after being diagnosed. This is better than other types of mesothelioma, which have a one-year to 21-month life expectancy.

A patient’s prognosis can be influenced by a number of circumstances, including:

  • Type of mesothelioma cell
  • Size and stage of the tumor
  • Patient’s age

The malignant cells, like those found in other kinds of mesothelioma, have a fast development rate and the ability to spread swiftly. Furthermore, there is a high likelihood of recurrence. According to one study, the recurrence rate is at least 53%, with at least 60% of recurrences occurring within two years of successful therapy. According to studies, those with recurrent testicular mesothelioma have a 14-month life expectancy.

Asbestos and Testicular Mesothelioma: What Causes It?

It’s unclear how asbestos fibers end up in the tunica vaginalis to begin with. Asbestos fibers are inhaled or ingested in the cases of pleural and peritoneal mesothelioma, respectively.

They then travel to the lungs or the digestive tract. It’s unclear what path asbestos fibers take to reach the tunica vaginalis at this time.

However, they are unable to be evacuated once they have entered this sensitive tissue. Instead, they spend years or decades stuck deep within the tunica vaginalis. After a lengthy period of producing irritation and inflammation, otherwise healthy cells finally become abdominal and begin to divide.

Cancer is caused by unchecked cell development, which eventually leads to death. Cancer spreads through the body, shutting down adjacent organs and infiltrating the immunological filtration system (lymphatic system).

Testicular mesothelioma, like all malignancies, can be managed or prevented with early treatment. Doctors can stop testicular mesothelioma from spreading to other parts of the body and give the patient a greater chance of life if they catch it early.

Contact a Mesothelioma Specialist for Testicular Mesothelioma

Because mesothelioma is such a rare kind of cancer, it can only be adequately treated by clinicians with substantial experience in mesothelioma research and therapy.

If you or someone you care about has been diagnosed with testicular mesothelioma, it’s critical to seek a second opinion from a professional. General oncologists lack the knowledge and experience needed to create effective treatment strategies.

At treatment centers across the country, top mesothelioma specialists are accepting new patients.

Here are some of the top mesothelioma specialists available to treat you:

  • Dr. David Jablons, UCSF Helen Diller Family Comprehensive, San Francisco CA
  • Dr. Brian Loggie, CHI Health Clinic, Omaha NE
  • Dr. Edward Levine, Wake Forest University Medical Center, Winston-Salem NC

Patients with testicular mesothelioma may be entitled to financial compensation to cover treatment costs, travel expenses, and other damages. Patients with mesothelioma are the victims of asbestos producers’ negligence. As a result, victims may pursue claims or lawsuits against numerous firms that deliberately endangered their health.

Contact our Patient Advocates right away if you’ve been diagnosed with mesothelioma. We’re here to analyze your case and connect you with an expert legal team who can assist you in successfully filing a claim.


Surgery is the most common treatment for testicular mesothelioma. In the 2019 study, nearly all
of the 113 testicular mesothelioma patients (98.2%) had their tumor surgically removed.
The damaged testicle and the complete spermatic cord are removed during this treatment. If the
cancer has spread to surrounding lymph nodes, doctors will do a lymphadenectomy operation to
remove these as well.
It is sometimes a secondary tumor, with the initial tumor occurring within
the peritoneum (the membrane that lines the abdominal cavity). Doctors must treat the patient for
peritoneal mesothelioma in circumstances like this.
Contact a Mesothelioma Specialist for Testicular Mesothelioma
Because mesothelioma is such a rare kind of cancer, it can only be adequately treated by
clinicians with substantial experience in mesothelioma research and therapy.
If you or someone you care about has been diagnosed with testicular mesothelioma, it's critical to
seek a second opinion from a professional. General oncologists lack the knowledge and
experience needed to create effective treatment strategies.
At treatment clinics across the country, prominent mesothelioma specialists are accepting new

Is mesothelioma curable?

Unfortunately, mesothelioma is a disease that is generally aggressive, and there is no cure for most people. Mesothelioma is usually discovered when the cancer has progressed to the point that it can no longer be removed surgically. Instead, your doctor may attempt to keep your cancer under control so that you can live a more pleasant life.

Has anyone survived mesothelioma?

Mesothelioma Survival Rate – Mesothelioma survival rates are normally 4–18 months after diagnosis, but some people with mesothelioma have lived for more than 10 years. The disease currently has a ten percent five-year survival rate.

How long has someone been living with mesothelioma?

A 37-year-old mesothelioma survivor thanks alternative medicine. Jerry Lampe may be the country’s longest-living mesothelioma survivor, and he’s as amazed as anyone that he’s still alive.

What is the most effective mesothelioma treatment?

Heated Intraperitoneal Chemotherapy (HIPEC): For peritoneal mesothelioma, HIPEC is the most effective therapeutic approach. Doctors deliver hot chemotherapy medications to the abdominal cavity following surgery using a special pump and infusion equipment.

Is it possible to cure mesothelioma if found early?

At this time, there is no cure for mesothelioma. While mesothelioma is incurable, there are more therapy options for early-stage mesothelioma, and palliative treatments can help with symptoms. When compared to mesothelioma discovered later, the prognosis for stage 1 mesothelioma is better.

Testicular mesothelioma

Mayo ClinicTesticular mesothelioma