Staging of brain cancer


Brain cancer is a brain disease in which cancer cells (malignant cells) develop in the tissue of the brain (cancer of the brain). Cancer cells multiply to form a tumor, which obstructs brain functions like muscular control, sensation, memory, and other normal bodily functions. Malignant tumors are made up mostly of cancer cells, while benign tumors are made up mostly of noncancerous cells. Primary brain tumors are cancer cells that arise from brain tissue, whereas metastatic or secondary brain tumors are cancer cells that travel from other parts of the body to the brain.

The staging procedure determines how far cancer has spread from its original location. The behavior of brain cancer differs from that of other malignancies. Although tumors can migrate within the brain, primary brain tumors seldom spread outside of the brain or away from the central nervous system (CNS).

As a result, rather of being staged, brain cancer is frequently graded. The brain tumor grading system has four levels and helps your medical team understand how the tumor is progressing. This method allows doctors to tailor brain cancer therapy to the specific demands of each patient.

Assessing brain tumors

Doctors focus on the characteristics of the tumor and its effect on functionality when determining the growth and development of tumors in the brain. The following are the primary factors used to evaluate brain tumors:

  • Dimensions and location
  • Types of tissues or cells that are harmed
  • Susceptibility to change (the likelihood that part or all of the tumor can be removed by surgery)
  • The malignancy has progressed to the brain or spinal cord.
  • There’s a chance the cancer has gone outside the brain or central nervous system.

A thorough examination will take into account your age as well as any brain cancer symptoms that are restricting basic capabilities like speech, hearing, or mobility.

The staging of brain cancer differs significantly from that of other tumors in the body. Lung, colon, and breast cancers are staged according to their location in the body, size, lymph node involvement, and potential dissemination. The aggressiveness of tumor cells under a microscope is used to grade brain tumors.

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How Is Brain Cancer Staged?

Tumor histology, age, symptoms, tumor residual, location, molecular characteristics, functional neurologic status, metastatic dissemination, and recurrences all have a role in prognosis.

Unlike other tumors, brain cancer is graded based on pathologic features, or how the cells appear under a microscope. The following are the grades/stages of brain cancer:

Grade 1: Brain tumors are either noncancerous or slow-growing. Its cells have the look of healthy cells and are frequently treated with surgery.

Grade 2: Brain tumors at this grade are malignant but slow-growing. Under a microscope, its cells appear to be odd. These tumors have the potential to spread to neighboring tissues or recur following treatment.

Grade 3: Brain tumors are malignant and progress faster than grade 1 and 2 tumors. The cancerous cells show severe abnormalities when seen under a microscope. Brain cancer in stage 3 can produce aberrant cells that can spread to other parts of the brain.

Grade 4: Cancer brain tumors in this stage develop quickly and exhibit a variety of aberrant features that can be detected under a microscope. The tumors in stage 4 brain cancer can spread to other parts of the brain and even generate blood vessels to keep up with their rapid growth. They may also contain small clumps of dead cells (necrosis).

Brain metastasis: Secondary brain tumors are far more common than primary brain tumors because they have spread to the brain from another part of the body. These tumors are also growing more common as cancer patients respond better to treatment and survive longer, allowing the original cancer to migrate to the brain.

Lung, breast, colon, kidney, melanoma, thyroid, and uterine malignancies are all known to spread to the brain. The most prevalent type of brain metastasis is lung cancer. In fact, a brain scan is frequently used in the staging of lung cancer.

The Tumor, Node, Metastasized (spread) staging classification will most likely be used to evaluate brain metastases (TNM). Individuals are sometimes diagnosed with brain or spinal metastases before they are aware that they have a primary malignancy.

Brain Cancer Types

There are hundreds of distinct types of brain malignancies because the brain is the most complicated organ in the body. Brain cancer can be classified as either primary or metastatic, with primary tumors originating in the brain and metastatic cancers spreading into the brain from another location in the body.


Glioblastoma is a stage 4 tumor that is one of the most dangerous types of brain cancer due to its relentless aggressiveness. It produces an increase in cerebral pressure. When a tumor grows large enough to take up more space inside the fixed volume of the skull, healthy brain tissue is squeezed.

Tumors can grow large enough to restrict the natural flow of cerebrospinal fluid in the brain, resulting in increased pressure. The following symptoms can be caused by increased intracranial pressure:

  • Headaches
  • Nausea
  • Vomiting
  • Uncertain perception
  • Confusion or a mental shift in one’s state of mind
  • Loss of mobility

Surgery to remove as much of the tumor as feasible, followed by chemotherapy and radiation, is now the best treatment for glioblastoma.

What are the causes of brain cancer?
Primary brain tumors can develop from a variety of brain tissues (for example, glial cells, astrocytes, and other brain cell types). The spread of cancer cells from one body organ to the brain is known as metastatic brain cancer. The causes of the transition from normal to malignant cells in both metastatic and primary brain tumors, however, are unknown. Researchers have discovered that persons who have certain risk factors are more likely to acquire brain cancer.

People with risk factors, such as working in an oil refinery, handling jet fuel or chemicals like benzene, chemists, embalmers, or rubber workers, have greater risks of brain cancer than the general population. Although some families have many members with brain cancer, there is no evidence that inheritance (the genetic transmission of features from parents to children) is a cause of brain tumors. Other risk factors for brain cancer have been hypothesized but not verified, such as smoking, radiation exposure, and viral infection (HIV). There is no proof that brain cancer is communicable, or that it is induced by head trauma or cell phone use. Although numerous articles in the popular press and on the internet claim that aspartame (an artificial sweetener) causes brain cancer, the FDA maintains that it does not and bases its conclusions on over 100 toxicological and clinical investigations.

What is the treatment for brain cancer?

Each patient with brain cancer has a unique treatment strategy. The treatment plan is created by specialists who specialize in brain cancer, and it varies greatly depending on the type of cancer, the location of the tumor in the brain, the size of the tumor, the patient’s age, and the patient’s overall health. The patient’s wishes also play an important role in the plan. Patients should talk to their doctors about their treatment options.

The most common treatments for brain cancer include surgery, radiation therapy, and chemotherapy. A combination of these treatments is frequently used in individual treatment programs. By removing the tumor away from normal brain tissue, surgical therapy seeks to eradicate all malignant cells. To distinguish it from noninvasive radiosurgery or radiation therapy, this surgery that includes opening the skull (craniotomy) is commonly referred to as invasive operation. Surgeons label some brain malignancies as inoperable because removing the malignancy could result in more brain damage or death. However, a brain tumour that one surgeon considers inoperable may be judged operable by another. Patients who have been diagnosed with an inoperable brain tumor should seek a second opinion before abandoning surgical treatment.

Radiation therapy aims to kill tumor cells by destroying their ability to function and replicate by focusing high-energy radiation on the tumor. Radiosurgery is a nonsurgical procedure that uses highly focused gamma-ray or X-ray beams to deliver a single high dose of precisely targeted radiation to the specific area or areas of the brain where the tumor or other abnormality is located, while minimizing the amount of radiation to healthy brain tissue. The radiation source used in radiosurgery varies; a gamma knife utilizes focused gamma rays, a linear accelerator uses photons, and heavy-charged particle radiosurgery uses a proton beam. Tomotherapy is a type of radiotherapy in which radiation is delivered in a highly accurate and customized manner to reduce radiation exposure to healthy tissue, and it has also been used to treat brain cancer.

Chemotherapy is a treatment that uses chemicals (drugs) to kill tumor cells. These chemicals (drugs) are designed to kill certain types of cancer cells. There are several chemical agents employed; specific medication therapy are numerous, and each regimen is usually tailored to the patient’s specific kind of brain cancer. For example, bevacizumab (Avastin) is a drug approved for treatment of glioblastomas (glioblastoma multiforme). Chemotherapy can be administered intrathecally (into the cerebrospinal fluid by a spinal tap or through a surgically placed permanent reservoir under the scalp attached through a sterile tubing placed into the fluid-containing chambers in the brain), by IV administration, and biodegradable chemically impregnated polymers. All treatments attempt to spare normal brain cells.

Hyperthermia (heat treatments), immunotherapy (immune cells directed to destroy certain cancer cell types), and steroids to lessen inflammation and brain swelling are all possible treatment options. These could be incorporated into other treatment programs.

Clinical trials (treatment programs devised by scientists and clinicians to test novel drugs or treatment methods on patients) are another option for individuals seeking treatment tailored to their specific cancer cell type. Clinical trials are an important aspect of the research process that aims to develop improved therapies for all diseases. Because research with patients is ongoing using these prospective therapies, stem cell therapeutics for brain and brain stem tumors and other disorders may be available. The finest brain cancer treatment is devised by a team of cancer professionals in consultation with the patient’s requests.


The best way to prevent brain cancer is to educate oneself about the numerous forms of cancers, their symptoms, and the various therapies available.

You don’t have to go through brain cancer alone if you or a loved one has been diagnosed. Please contact All American Hospice, and we will be happy to assist you and provide care.

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