Difference between Amitiza and Movantik

What is Amitiza?

Amitiza (lubiprostone) is a prescription drug with a brand name. In adults, it’s used to treat three types of constipation:

  • Idiopathic constipation is a type of chronic constipation that occurs for no apparent reason (CIC)
  • Females with IBS-C (irritable bowel syndrome with constipation)
  • Opioid-induced constipation (OIC) in persons who are using opioids for long-term pain that isn’t caused by cancer.

Amitiza belongs to the class of drugs known as chloride channel activators. It’s not a stool softener, a fiber, or a laxative in the classic sense. It does, however, have the same side effects as these other medicines. It helps move stool by increasing the amount of fluid in your intestines.

How Amitiza works
Amitiza belongs to the chloride channel activator class of medicines. Chloride channels can be found in practically every type of cell in your body. They’re proteins that help chemicals move across cell membranes.

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These chloride channels in your intestine are activated (activated) by Amitiza. The volume of fluid flowing into your intestine is increased as a result of this process. This extra fluid helps constipation by allowing feces to flow through your system more readily.

How long does it take to work?
Amitiza gets to work right away. For example, in a clinical studyTrusted Source, the use of Amitiza in people with chronic idiopathic constipation was investigated (CIC). Within 24 hours of taking the drug, almost 57 percent of the patients in the study had a bowel movement. Only 37% of those who got a placebo (no medicine) experienced this effect.

80 percent of those who took Amitiza had a bowel movement within 48 hours after starting medication. Only 61% of those in the placebo group experienced the same outcome.

What is Movantik?

Movantik is a prescription drug that is used to treat constipation caused by opioid prescription pain relievers in individuals who have long-term (chronic) pain that is not caused by active cancer. Movantik’s safety and efficacy in youngsters are unknown.

Difference between Amitiza and Movantik

Treats constipation.

  • Amitiza prescribed for Chronic Constipation, Irritable Bowel Syndrome, Opioid-Induced Constipation, Drug-Induced Constipation, and Constipation. Amitiza can be used for a variety of other things that aren’t covered in this pharmaceutical guide. If previous drugs haven’t worked, Amitiza (lubiprostone) is a good but pricey alternative for treating severe constipation.


  • Movantik prescribed for Opioid-Induced Constipation, Chronic Constipation, and Drug-Induced Constipation. Movantik can be used for a variety of other things that aren’t covered in this pharmaceutical guide. Movantik (naloxegol) is an effective treatment for constipation caused by opiate use. It can, however, induce adverse effects that make you feel as if you’re going through opioid withdrawal.

Drug Class

  • Drug Class of Amitiza is Chloride channel activators
  • Drug Class of Movantik is Peripheral opioid receptor antagonists


  • Amitiza (lubiprostone) is an effective treatment for severe constipation that has failed to respond to conventional treatments.

          Amitiza (lubiprostone) can help you have better bowel habits, less straining, and more consistent stool.


  • If standard laxatives haven’t worked for you, Movantik (naloxegol) is a good alternative.

          Movantik (naloxegol) should only be used once a day.

This drug has no effect on your heart when compared to alternatives.


  • Amitiza (lubiprostone) does not have a generic version and may be more expensive than other options.

         Amitiza (lubiprostone) has not been thoroughly tested in persons who suffer from constipation as a result of cancer or cancer therapy.

        Amitiza should be used with caution by those who have liver disorders (lubiprostone).


  • In persons who are taking certain opiates, such as methadone, the side effects of Movantik (naloxegol), such as withdrawal and lack of pain control, may be exacerbated.

Traditional laxatives are less expensive. There isn’t a generic version accessible.

This drug must be taken on an empty stomach to be effective.

If you have kidney difficulties, you may need to take a lower dose of Movantik (naloxegol), which may be                 less effective or cause more side effects.

Applied to

  • Amitiza (lubiprostone) is applied to Constipation
  • Movantik (naloxegol) is applied to Opioid induced constipation

Pricing and Coupons


Amitiza (lubiprostone)

·         Quantity ·         60 capsule
·         Dosage ·         8 mcg
·         Per Unit* ·         $6.62
·         Cost* ·         $396.93


Movantik (naloxegol)

  • Quantity : 30 tablet
  • Dosage 25 mg
  • Per Unit* $12.68 – $13.05
  • Cost* $380.52 – $391.60

Dosage Form(s) Available

Amitiza (lubiprostone)

  • Oral capsule

Movantik (naloxegol)

  • Oral tablet

Drug Interactions

Amitiza (lubiprostone)

Amitiza is known to interact with the following drugs:

  • 1 medication interaction that is mild (2 brand and generic names)

Movantik (naloxegol)

There are 168 medications that have been documented to interact with Movantik:

  • 58 significant medication interactions (183 brand and generic names)
  • 51 medication interactions that are mild (171 brand and generic names)
  • 59 medication interactions that are minimal (160 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Amitiza (lubiprostone)

There are no known interactions between alcohol and food. This isn’t to say there aren’t any interactions. Always seek medical advice from a qualified professional.

Movantik (naloxegol)

During naloxegol treatment, do not drink grapefruit or grapefruit juice. Grapefruit juice can considerably raise naloxegol levels in the blood. Sweating, tears, runny nose, chills, diarrhea, abdominal discomfort, anxiety, sleeplessness, irritability, restlessness, and yawning are all possible side effects and withdrawal symptoms. Taking naloxegol with food can potentially increase the amount of naloxegol in your system.

Disease Interactions

Amitiza (lubiprostone)

Movantik (naloxegol)

Side effects

1 Amitiza (lubiprostone) has 14 possible side effects

  • Diarrhea
  • Headache
  • Abdominal pain
  • Abdominal bloating
  • Gas
  • Vomiting
  • Loose stools
  • Abdominal discomfort
  • Dizziness
  • Swelling
  • Indigestion
  • Fatigue
  • Chest discomfort/painShortness of breath


  Movantik (naloxegol) has 7 possible side effects 

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Gas
  • Vomiting
  • Headache
  • Excess sweating

Risks and risk factors

Risks and risk factors of Amitiza (lubiprostone) are

  • Nausea
  • Diarrhea
  • Low blood pressure

Medicines that lower blood pressure

  • Trouble breathing
  • Bowel obstruction

Bowel blockage

  • Higher risk of side effects

Liver problems

Difference between Amitiza and Movantik

Risks and risk factors of Movantik (naloxegol) are 

  • Opioid withdrawal & reduced pain relief

Methadone use

  • Severe abdominal pain and/or diarrhea

Movantik 25mg

  • Stomach or intestinal holes

Crohns disease

Peptic ulcer disease

Diverticular disease

Stomach malignancies

Difference between Amitiza and Movantik

Difference between Amitiza and Movantik